---
title: >-
  Standard error estimation for transported effects in sequential nested trial
  emulations using M-estimation
description: Catie Wiener · with Chase Latour, Jeanny Wang, Paul Zivich, Alan Brookhart
date: '2026-09-02'
category: Events
canonical_url: https://www.headwaterscience.com/resources/events/other/ispe-2026-poster-c-350/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: ispe-2026-poster-c-350
id: 7HlZrd2RIuY4do8hhW2Cot
contentType: article
---

Poster · C-350 · Wed 2 Sep · 12:00–1:30 PM CEST

# Standard errors for transported effects, without the bootstrap.

A methods poster on standard-error estimation for sequential nested trial emulation with transportability.


![ISPE 2026 event hero background](https://images.ctfassets.net/fea4lj2cdgl5/7I2tVYn8fivb9Cd2IBEk48/a0c18a6f721a2264369580e73aab9aa0/ispe-2026-event-background.png?w=1920&fm=webp&q=75)

## Inference for transported real-world effects.

Sequential nested trial emulation reduces immortal-time bias, but it complicates standard-error estimation, especially once you transport the estimate to a target population. The common fix, nonparametric bootstrap, can be computationally heavy.

This poster examines M-estimation as an alternative approach to standard-error estimation in that setting. It is a methods talk for teams doing transportability and target-trial-emulation work.

- Methods and simulation study
- Topic: standard errors for transported effects
- M-estimation as an alternative to the bootstrap

Citation

Wiener C, Latour C, Wang J, Zivich P, Brookhart A. Standard error estimation for transported effects in sequential nested trial emulations using M-estimation. Poster C-350, 42nd ISPE Annual Meeting; August 29–September 2, 2026; Milan, Italy.

## Schedule a meeting

Share your focus and a preferred day or time in the comments, and we will confirm a slot.

*Interactive embed: Pardot Form.*