---
title: >-
  Achieving the UNAIDS 90-90-90 targets: a comparative analysis of four large
  community randomised trials delivering universal testing and treatment to
  reduce HIV transmission in sub-Saharan Africa.
description: >-
  Explore this publication on real-world evidence: Achieving the UNAIDS 90-90-90
  targets: a comparative analysis of four large community randomised trials…
date: '2022-01-01'
category: Publications
tags:
  - Botswana Harvard AIDS Institute Partnership
  - HIV
  - Abstract/Manuscript
  - University of California San Francisco
  - University of California Berkeley
  - Care
  - 'No'
  - Health System Partner
  - Centers for Disease Control and Prevention
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/acad-botswana-harvard-aids-institute-partnership/achieving-the-unaids-90-90-90-targets-a-comparative/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: achieving-the-unaids-90-90-90-targets-a-comparative
id: 5gLb0KVynhKB0FB0EiOCU0
contentType: article
---

## Challenge

Four large community-randomized UTT trials achieved variable success in reaching UNAIDS 90-90-90 targets, but no cross-trial comparison had systematically analyzed the approaches used to measure cascade coverage and the factors explaining differences across settings.

## Solution

Target RWE's HIV team and multi-trial collaborators conducted a systematic comparative analysis of 90-90-90 target achievement across the four UTT trials, examining cascade measurement approaches, intervention delivery methods, and contextual factors that explain cross-trial differences.

## Impact

Synthesizing evidence across four large UTT trials provides global HIV program designers and funders with actionable insights on implementation strategies that most reliably drive 90-90-90 achievement.

## Use Cases / Links

Cross-UTT-trial 90-90-90 target achievement analysis for global HIV program design and scale-up, Evidence synthesis for HIV combination prevention program optimization across diverse settings