---
title: >-
  Advancing Principled Pharmacoepidemiologic Research to Support Regulatory and
  Healthcare Decision Making: The Era of Real-World Evidence
description: >-
  Explore this publication on real-world evidence: Advancing Principled
  Pharmacoepidemiologic Research to Support Regulatory and Healthcare Decision
  Making: The…
date: '2025-01-01'
author: M. Alan Brookhart, PhD, Jennifer B. Christian
category: Publications
tags:
  - GSK
  - Emory University
  - Amgen Inc.
  - University of North Carolina at Chapel Hill
  - Abstract/Manuscript
  - Pharma Partner
  - Aarhus University
  - Clinical Pharmacology & Therapeutics
  - Approval & Commercialization
  - 'Yes'
  - Regeneron Pharmaceuticals
  - Health System Partner
  - National Cheng Kung University
  - Methods/Pharmacoepi
  - R&D
  - Columbia University
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/ind-gsk/advancing-principled-pharmacoepidemiologic-research-to/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: advancing-principled-pharmacoepidemiologic-research-to
id: 5kYgEkFnIcmeEVLZCkhe4b
contentType: article
---

## Challenge

Pharmacoepidemiology lacked a consolidated framework articulating the methodological, regulatory, and technological factors driving the evolution of real-world evidence as a credible input to healthcare decision-making.

## Solution

Target RWE's scientific leadership co-authored a landmark review in Clinical Pharmacology & Therapeutics synthesizing the four forces driving the RWE era: rich healthcare data, advanced extraction technologies, principled causal inference methods, and global regulatory guidance.

## Impact

Establishing a rigorous intellectual framework for principled pharmacoepidemiology positions Target RWE as a thought leader shaping how regulators, payers, and clinicians evaluate RWE.

## Use Cases / Links

Thought leadership establishing principled pharmacoepidemiology framework for regulatory RWE acceptance, Scientific positioning of Target RWE as a leader in causal inference-based evidence generation