---
title: >-
  Preexposure prophylaxis uptake, adherence, and persistence during
  periconception periods among women in South Africa.
description: >-
  Explore this publication on real-world evidence: Preexposure prophylaxis
  uptake, adherence, and persistence during periconception periods among women
  in South…
date: '2024-01-01'
category: Publications
tags:
  - HIV
  - University of North Carolina at Chapel Hill
  - Abstract/Manuscript
  - Care
  - 'No'
  - Health System Partner
  - Harvard T.H. Chan School of Public Health
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/di-hiv/preexposure-prophylaxis-uptake-adherence-and-persistence/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: preexposure-prophylaxis-uptake-adherence-and-persistence
id: FbvgK5fZpRGGafkqVQ1Am
contentType: article
---

## Challenge

PrEP uptake, adherence, and persistence among South African women during the periconception period had been studied cross-sectionally but longitudinal patterns across conception attempts had not been characterized.

## Solution

Target RWE's HIV team and collaborators analyzed longitudinal PrEP use data among periconception South African women, characterizing uptake, objective adherence trajectories, and persistence patterns across conception attempts.

## Impact

Providing longitudinal PrEP adherence evidence for periconception South African women informs the design of adherence-enhancing interventions tailored to the specific demands of conception planning.

## Use Cases / Links

Longitudinal periconception PrEP adherence characterization for HIV prevention program design, Objective PrEP persistence evidence supporting adherence intervention development for South African women