---
title: >-
  G-computation for policy-relevant effects of interventions on time-to-event
  outcomes.
description: >-
  Explore this publication on real-world evidence: G-computation for
  policy-relevant effects of interventions on time-to-event outcomes..
date: '2020-01-01'
category: Publications
tags:
  - University of North Carolina at Chapel Hill
  - Alexander Breskin
  - Approval & Commercialization
  - 'Yes'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/acad-university-of-north-carolina-at-chapel-hill/g-computation-for-policy-relevant-effects-of-interventions/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: g-computation-for-policy-relevant-effects-of-interventions
id: 4wBq0iuZJ0zCyjYE82RenR
contentType: article
---

## Challenge

G-computation is a powerful tool for estimating policy-relevant causal effects of time-varying interventions on time-to-event outcomes, but practical implementation guidance including estimation, variance, and interpretation was not available in an accessible reference.

## Solution

Target RWE researchers and UNC collaborators published a methodological paper providing accessible implementation guidance for g-computation applied to policy-relevant causal effects of interventions on time-to-event outcomes.

## Use Cases/Links

[Read the publication](https://academic.oup.com/ije/article/49/6/2021/5952897)