---
title: >-
  Using Negative Control Outcomes to Assess the Comparability of Osteoporosis
  Treatment Groups.
description: >-
  Explore this publication on real-world evidence: Using Negative Control
  Outcomes to Assess the Comparability of Osteoporosis Treatment Groups..
date: '2018-01-01'
category: Publications
tags:
  - University of North Carolina at Chapel Hill
  - Osteoporosis/Bone
  - ICPE
  - Care
  - 'No'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/acad-university-of-north-carolina-at-chapel-hill/using-negative-control-outcomes-to-assess-the-comparability/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: using-negative-control-outcomes-to-assess-the-comparability
id: 69I0jJu9gBZinUDN2jIkn2
contentType: article
---

## Challenge

This is an earlier presentation of the osteoporosis NCO methodology (see Rows 15 and 50). Initial conference presentation establishing that NCOs can assess comparability of osteoporosis treatment groups in a real-world study with known confounding by frailty and bone density.

## Solution

Target RWE researchers presented the NCO methodology applied to osteoporosis treatment groups at ISPOR 2018, demonstrating how NCO balance or imbalance reveals residual confounding and providing early empirical evidence for NCO utility.