---
title: >-
  A Practical Example Demonstrating the Utility of Single-world Intervention
  Graphs.
description: >-
  Explore this publication on real-world evidence: A Practical Example
  Demonstrating the Utility of Single-world Intervention Graphs..
date: '2018-01-01'
category: Publications
tags:
  - Breskin, Alexander
  - University of North Carolina at Chapel Hill
  - Approval & Commercialization
  - 'Yes'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/author-breskin-alexander/a-practical-example-demonstrating-the-utility-of-single/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: a-practical-example-demonstrating-the-utility-of-single
id: 7yOeLClYsbVx3YZ6dSxYuO
contentType: article
---

## Challenge

Single-world intervention graphs—which integrate the potential outcomes framework explicitly into causal diagrams—had been developed theoretically but lacked a practical worked example demonstrating their utility for identifying causal effects in the presence of selection bias.

## Solution

Target RWE researchers and UNC collaborators published a practical example in Epidemiology demonstrating how SWIGs supplement traditional causal DAGs to reveal identifiability conditions necessary to estimate treatment effects from observed data in a vaccine trial with dropout.

## Use Cases/Links

[Read the publication](https://journals.lww.com/epidem/Fulltext/2018/05000/A_Practical_Example_Demonstrating_the_Utility_of.20.aspx)