---
title: >-
  Comparing causal estimands from a sequential nested trial emulation with a
  treatment decision design to a conventional single point randomized trial: A
  simulation study.
description: >-
  Explore this publication on real-world evidence: Comparing causal estimands
  from a sequential nested trial emulation with a treatment decision design to
  a…
date: '2024-01-01'
category: Publications
tags:
  - Kathleen Hurwitz
  - M Alan Brookhart
  - Catherine Wiener
  - Approval & Commercialization
  - 'Yes'
  - Chase D. Latour
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/author-kathleen-hurwitz/comparing-causal-estimands-from-a-sequential-nested-trial/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: comparing-causal-estimands-from-a-sequential-nested-trial
id: 56bPfT2PWlN8SNbldsMMvd
contentType: article
---

## Challenge

Sequential nested trial emulation and treatment decision designs address dynamic treatment questions differently, but no direct comparison of the causal estimands they target had been conducted.

## Solution

Target RWE researchers presented a formal comparison of causal estimands from sequential nested trial emulation versus treatment decision designs, clarifying when each design's estimand aligns with different regulatory and clinical decision-making objectives.