---
title: >-
  Fracture Risk Estimation in Post-menopausal Women: A Comparison of Machine
  Learning Methods and Software Systems.
description: >-
  Explore this publication on real-world evidence: Fracture Risk Estimation in
  Post-menopausal Women: A Comparison of Machine Learning Methods and Software…
date: '2022-01-01'
category: Publications
tags:
  - M Alan Brookhart
  - Amgen Inc.
  - Osteoporosis/Bone
  - ICPE
  - David Pritchard
  - Matthew Phelan
  - Care
  - 'Yes'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/author-m-alan-brookhart/fracture-risk-estimation-in-post-menopausal-women-a/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: fracture-risk-estimation-in-post-menopausal-women-a
id: 5qfnP4uK1Su9uhNVrM4SsA
contentType: article
---

## Challenge

Fracture risk prediction in post-menopausal women relies on established scoring tools, but whether machine learning methods could outperform or complement traditional software-based tools in a real-world commercial insurance population had not been evaluated.

## Solution

Target RWE researchers compared ML algorithms against traditional fracture risk estimation tools in a cohort of commercially insured post-menopausal women, evaluating predictive performance and characterizing which patient characteristics drive differential model performance.