---
title: >-
  The Effect of Remdesivir for The Treatment of COVID-19 on Mortality Among
  Hospitalized Patients.
description: >-
  Explore this publication on real-world evidence: The Effect of Remdesivir for
  The Treatment of COVID-19 on Mortality Among Hospitalized Patients..
date: '2022-01-01'
category: Publications
tags:
  - M Alan Brookhart
  - COVID-19
  - Catherine Wiener
  - ICPE
  - Care
  - 'Yes'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/author-m-alan-brookhart/the-effect-of-remdesivir-for-the-treatment-of-covid-19-on/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: the-effect-of-remdesivir-for-the-treatment-of-covid-19-on
id: 3d30ftW7A8FhOmdZnf8XqV
contentType: article
---

## Challenge

Remdesivir's effectiveness for reducing in-hospital mortality in COVID-19 patients was contested in early observational studies due to methodological limitations including immortal time bias and failure to account for time-varying treatment.

## Solution

Target RWE researchers analyzed hospital chargemaster data using rigorous causal methods to estimate the effect of remdesivir on in-hospital mortality, addressing key biases that had compromised earlier studies and stratifying results by oxygen supplementation level.