---
title: 'Bridged treatment comparisons: an illustrative application in HIV treatment.'
description: >-
  Explore this publication on real-world evidence: Bridged treatment
  comparisons: an illustrative application in HIV treatment..
date: '2022-01-01'
category: Publications
tags:
  - HIV
  - University of North Carolina at Chapel Hill
  - Alexander Breskin
  - Care
  - 'Yes'
  - Oral Presentation
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/di-hiv/bridged-treatment-comparisons-an-illustrative-application/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: bridged-treatment-comparisons-an-illustrative-application
id: 1Sku3L7b7a2N0QFHtNUONx
contentType: article
---

## Challenge

Direct head-to-head comparisons of antiretroviral therapy regimens are not always feasible through trial designs sharing a common comparator arm, but no formal methodology existed for combining data across trials to make these bridged treatment comparisons in HIV research.

## Solution

Target RWE researchers and UNC collaborators applied the data fusion estimator to an HIV treatment comparison, using shared trial arms from ACTG 175 and ACTG 320 to estimate the indirect effect of triple versus mono antiretroviral therapy.

## Use Cases/Links

[Read the publication](https://arxiv.org/abs/2206.04445)