---
title: >-
  Real-World Dose Trajectory Patterns and Impact on Polypharmacy Burden and New
  Antiseizure Medication (ASM) Prescriptions in Patients With Dravet Syndrome
  (DS), Lennox-Gastaut Syndrome (LGS), or Tuberous Sclerosis Complex (TSC)
  Receiving Cannabidiol (CBD)
description: >-
  Explore this publication on real-world evidence: Real-World Dose Trajectory
  Patterns and Impact on Polypharmacy Burden and New Antiseizure Medication
  (ASM)…
date: '2026-01-01'
category: Publications
tags:
  - Jazz Pharmaceuticals
  - Poster Presentation
  - Approval & Commercialization
  - 'No'
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/ind-jazz-pharmaceuticals/real-world-dose-trajectory-patterns-and-impact-on/
source: Headwater
license: © 2026 Headwater. All rights reserved.
slug: real-world-dose-trajectory-patterns-and-impact-on
id: 7F723YUhHpRN0pXwcHeu4F
contentType: article
---

## Challenge

Real-world dose trajectory patterns for CBD in epilepsy patients had not been characterized, limiting understanding of how CBD is optimized in clinical practice.

## Solution

Target RWE researchers analyzed longitudinal CBD dose trajectory data in real-world epilepsy patients, characterizing dose titration patterns, time to stable dosing, and the relationship between dose trajectory and ASM polypharmacy burden.