---
title: Methods and New Approaches in Pragmatic Trials
description: >-
  Explore this publication on real-world evidence: Methods and New Approaches in
  Pragmatic Trials.
date: '2023-01-01'
author: Kathleen Hurwitz, Jennifer B. Christian
category: Publications
tags:
  - ICPE
  - Approval & Commercialization
  - 'Yes'
  - Oral Presentation
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/icpe/methods-and-new-approaches-in-pragmatic-trials/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: methods-and-new-approaches-in-pragmatic-trials
id: 4GNlLDVseQNtPRJBSRGfdF
contentType: article
---

## Challenge

Pragmatic trial design integrates real-world elements but best practices for navigating the methodological trade-offs these design choices create had not been systematically presented to a pharmacoepidemiology audience.

## Solution

Target RWE researchers presented an oral session on methods and new approaches in pragmatic trials, covering key design principles, the tension between internal and external validity, and novel analytic strategies for extracting causal evidence from pragmatic trial data.

## Impact

Positioning Target RWE as a leader in pragmatic trial methodology extends the company's scientific influence into hybrid trial-registry designs, opening commercial opportunities with pharma partners.

## Use Cases / Links

Pragmatic trial design methodology education for hybrid trial-registry clinical development programs, Target RWE methodology positioning for hybrid trial-real world evidence programs