---
title: >-
  Risk Factors for Mortality and Intensive Care Requirements Among Pediatric
  Patients Hospitalized with COVID-19 in the United States
description: >-
  Explore this publication on real-world evidence: Risk Factors for Mortality
  and Intensive Care Requirements Among Pediatric Patients Hospitalized with…
date: '2022-01-01'
author: M. Alan Brookhart, PhD, Nuvan Rathnayaka
category: Publications
tags:
  - COVID-19
  - ICPE
  - Care
  - 'Yes'
  - Oral Presentation
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/di-covid-19/risk-factors-for-mortality-and-intensive-care-requirements/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: risk-factors-for-mortality-and-intensive-care-requirements
id: 4BAhZce0X4axnvR5duFjFU
contentType: article
---

## Challenge

The clinical characteristics and risk factors for mortality and ICU requirements among pediatric COVID-19 patients hospitalized in the US were poorly understood and underrepresented in early COVID-19 studies.

## Solution

Target RWE researchers analyzed hospital chargemaster data to characterize pediatric COVID-19 inpatients across US hospitals, identifying clinical risk factors for ICU admission and in-hospital mortality using multivariable regression models.

## Impact

Characterizing pediatric COVID-19 severity and its risk factors fills a critical early evidence gap, supporting public health guidance on pediatric COVID-19 management and informing therapeutic intervention design.

## Use Cases / Links

Pediatric COVID-19 severity characterization for clinical guideline development and therapeutic program design, Real-world risk factor evidence for ICU and mortality in hospitalized pediatric COVID-19 patients