---
title: >-
  The Effect of Remdesivir for The Treatment of COVID-19 on Mortality Among
  Hospitalized Patients
description: >-
  Explore this publication on real-world evidence: The Effect of Remdesivir for
  The Treatment of COVID-19 on Mortality Among Hospitalized Patients..
date: '2022-01-01'
author: M. Alan Brookhart, PhD, Catherine Wiener
category: Publications
tags:
  - COVID-19
  - ICPE
  - Care
  - 'Yes'
  - Oral Presentation
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/di-covid-19/the-effect-of-remdesivir-for-the-treatment-of-covid-19-on/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: the-effect-of-remdesivir-for-the-treatment-of-covid-19-on
id: 3d30ftW7A8FhOmdZnf8XqV
contentType: article
---

## Challenge

Remdesivir's effectiveness for reducing in-hospital mortality in COVID-19 patients was contested in early observational studies due to methodological limitations including immortal time bias and failure to account for time-varying treatment.

## Solution

Target RWE researchers analyzed hospital chargemaster data using rigorous causal methods to estimate the effect of remdesivir on in-hospital mortality, addressing key biases that had compromised earlier studies and stratifying results by oxygen supplementation level.

## Impact

Providing a causally rigorous estimate of remdesivir's real-world effectiveness on in-hospital mortality supports Gilead's post-authorization evidence strategy and demonstrates the value of Target RWE's causal inference-first approach.

## Use Cases / Links

Causally rigorous remdesivir effectiveness evidence for in-hospital COVID-19 mortality reduction, Post-authorization real-world effectiveness evidence supporting Gilead remdesivir label strategy