---
title: >-
  Use of negative control outcomes to detect mismeasured confounders in
  administrative data
description: >-
  Explore this publication on real-world evidence: Use of negative control
  outcomes to detect mismeasured confounders in administrative data..
date: '2021-01-01'
category: Publications
tags:
  - ICPE
  - Approval & Commercialization
  - 'No'
  - Oral Presentation
  - Methods/Pharmacoepi
  - R&D
canonical_url: >-
  https://www.headwaterscience.com/resources/publications/icpe/use-of-negative-control-outcomes-to-detect-mismeasured/
source: Headwater Science
license: © 2026 Headwater Science. All rights reserved.
slug: use-of-negative-control-outcomes-to-detect-mismeasured
id: 11KUkDsgUTdEIO9Uyk5xwy
contentType: article
---

## Challenge

Mismeasured confounders in administrative claims data are a recognized source of bias, but the utility of NCOs as a detection tool for confounders that are present but systematically miscoded had not been formally evaluated.

## Solution

Target RWE researchers presented an oral analysis demonstrating how NCOs can be used to detect the presence of mismeasured confounders in administrative data, extending the NCO framework beyond its traditional unmeasured confounding application.

## Impact

Extending NCO applications to mismeasured confounder detection broadens the utility of Target RWE's NCO-based validity checking toolkit, covering both unmeasured and miscoded confounding threats.

## Use Cases / Links

NCO application extension to mismeasured confounder detection in administrative claims data studies, Bias detection methodology advancement for Target RWE's NCO validity checking portfolio