University of North Carolina at Chapel HillAlexander BreskinApproval & CommercializationYesOral PresentationR&D
Commentary: Compositional data call for complex interventions.
Commentary: Compositional data call for complex interventions
Challenge
Compositional data—where components sum to a constant—violate standard regression assumptions, and standard analytic approaches applied to this data type can yield misleading causal estimates about the effects of behavioral interventions.
Solution
Target RWE researchers contributed a commentary in IJE highlighting the methodological challenges of compositional data in epidemiology and the need for methods that appropriately handle the constrained nature of such data when estimating intervention effects.