Brookhart MAUniversity of North Carolina at Chapel HillYu YAbstract/ManuscriptLatour CDApproval & CommercializationYesR&D
Controlling for Differential Regression-To-The-Mean via Propensity Scores: A Simulation Study.
Controlling for Differential Regression-To-The-Mean via Propensity Scores: A Simulation Study
Challenge
Regression-to-the-mean is a well-known source of bias in before-after treatment comparisons, but whether propensity score methods can effectively control for differential RTM when groups differ in baseline risk had not been rigorously evaluated through simulation.
Solution
Target RWE researchers conducted a simulation study examining the performance of propensity score methods in controlling for differential regression-to-the-mean, characterizing scenarios where standard PS adjustment succeeds or fails to remove this form of bias.