M Alan BrookhartUniversity of North Carolina at Chapel HillAbstract/ManuscriptDavid PritchardApproval & CommercializationYesAmgenR&D
Pragmatic considerations for negative control outcome studies to guide non-randomized comparative analyses: A narrative review.
Pragmatic considerations for negative control outcome studies to guide non-randomized comparative analyses: A narrative review
Challenge
Negative control outcome studies are increasingly used to evaluate unmeasured confounding in comparative effectiveness research, but practical guidance on how to select, implement, and interpret NCOs in real-world pharmacoepidemiologic settings was lacking.
Solution
Target RWE researchers co-authored a narrative review in Pharmacoepidemiology & Drug Safety synthesizing pragmatic considerations for NCO study design, including domain-based confounding identification, NCO selection criteria, and interpretation frameworks for non-null findings.