The Effect of Remdesivir for The Treatment of COVID-19 on Mortality Among Hospitalized Patients.

Challenge

Remdesivir's effectiveness for reducing in-hospital mortality in COVID-19 patients was contested in early observational studies due to methodological limitations including immortal time bias and failure to account for time-varying treatment.

Solution

Target RWE researchers analyzed hospital chargemaster data using rigorous causal methods to estimate the effect of remdesivir on in-hospital mortality, addressing key biases that had compromised earlier studies and stratifying results by oxygen supplementation level.