M Alan BrookhartUniversity of North Carolina at Chapel HillApproval & CommercializationYesDuke University School of MedicineOral PresentationDurham Veterans Affairs Medical CenterR&D
Using Instrumental Variables to Address Bias from Unobserved Confounders.
Using Instrumental Variables to Address Bias from Unobserved Confounders
Challenge
Instrumental variable methods offer the potential to address unobserved confounding in observational studies, but their application, assumptions, and interpretation in comparative safety and effectiveness research were not accessible to a general clinical audience.
Solution
Target RWE's scientific advisor Alan Brookhart co-authored a JAMA Guide to Statistics and Methods on instrumental variable analysis, providing a non-technical accessible introduction to IV principles, assumptions, and interpretation.