Bridged treatment comparisons: an illustrative application in HIV treatment.
Bridged treatment comparisons: an illustrative application in HIV treatment
Challenge
Direct head-to-head comparisons of antiretroviral therapy regimens are not always feasible through trial designs sharing a common comparator arm, but no formal methodology existed for combining data across trials to make these bridged treatment comparisons in HIV research.
Solution
Target RWE researchers and UNC collaborators applied the data fusion estimator to an HIV treatment comparison, using shared trial arms from ACTG 175 and ACTG 320 to estimate the indirect effect of triple versus mono antiretroviral therapy.