Characterizing the Distribution of Multiple Negative Control Outcome Risk Differences.

Challenge

Multiple NCOs are frequently analyzed simultaneously to assess unmeasured confounding, but the statistical distribution of NCO risk differences under different confounding scenarios had not been characterized.

Solution

Target RWE researchers presented an oral analysis characterizing the distribution of multiple NCO risk differences under varying confounding levels, providing a statistical framework for interpreting multi-NCO results and distinguishing true confounding signals from chance variation.