Company Overview
Headwater Science builds the advanced study designs, analytic frameworks, and tooling that consequential evidence increasingly requires.
Company Overview
Headwater Science builds the advanced study designs, analytic frameworks, and tooling that consequential evidence increasingly requires.
Built for the standard the field is moving toward
Real-world evidence is now an input to drug development, regulatory submission, and clinical decision-making. The methodological expectations that come with it have risen accordingly: pre-specification, protection against bias, sensitivity analysis, and the ability to withstand scrutiny from reviewers who didn't run the study. Headwater exists to meet that bar.
We partner with life sciences partners, academic research groups, regulatory bodies, and other research organizations on the analytical and design problems where standard approaches and current platforms aren't sufficient.
How Headwater engages
Headwater Science engages with research partners across three distinct modes, each tailored to where in the research process methodological capability is most needed.
Direct sponsor engagements
Headwater Science works with life sciences sponsors directly on their own studies, regardless of whether the underlying data comes from Pedestal Health's cohorts, sponsor-owned data assets, claims databases, electronic health records, or other research data sources. The engagement model varies: methodological consulting on a specific submission, end-to-end design and analysis of a comparative effectiveness study, target trial emulation of a randomized question that wasn't or couldn't be studied directly, or technology deployment to support an ongoing program.
Academic and research partnerships
Headwater Science methodologists collaborate with academic research groups, regulatory science partners, and other research organizations on methodological development and applied work. Many of Headwater Science's published methodological papers are co-authored with academic collaborators at the University of North Carolina at Chapel Hill and other institutions, reflecting the company's commitment to methodological development as a public scientific contribution rather than a proprietary capability.
Collaboration with Pedestal Health
Pedestal projects use Headwater Science methods and technology where the analytical complexity is highest — comparative effectiveness studies that require dynamic treatment design, regulatory-grade external control work, methodological consultation on submission packages, and the kinds of bias-protection frameworks that consequential evidence increasingly requires. The Pedestal collaboration is one expression of Headwater Science's work, not its definition.
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