Achieving the UNAIDS 90-90-90 targets: a comparative analysis of four large community randomised trials delivering universal testing and treatment to reduce HIV transmission in sub-Saharan Africa.

Four large community-randomized UTT trials achieved variable success in reaching UNAIDS 90-90-90 targets, but no cross-trial comparison had systematically analyzed the approaches used to measure cascade coverage and the factors explaining differences across settings.

Target RWE's HIV team and multi-trial collaborators conducted a systematic comparative analysis of 90-90-90 target achievement across the four UTT trials, examining cascade measurement approaches, intervention delivery methods, and contextual factors that explain cross-trial differences.

Synthesizing evidence across four large UTT trials provides global HIV program designers and funders with actionable insights on implementation strategies that most reliably drive 90-90-90 achievement.

Cross-UTT-trial 90-90-90 target achievement analysis for global HIV program design and scale-up, Evidence synthesis for HIV combination prevention program optimization across diverse settings