Fusion Designs for Indirect Treatment Effects

Fusion study designs that combine data from multiple sources to estimate indirect treatment effects lacked a formal estimator and identification framework, limiting their application to complex drug development questions.

Target RWE researchers developed and presented a formal estimator for indirect treatment effects using fusion designs, extending the fusion framework to handle treatment comparisons across multiple studies with shared arms.

Establishing a rigorous estimator for indirect treatment effects using fusion designs provides pharma partners with a principled method for generating bridged treatment comparisons when head-to-head trials are unavailable.

Fusion design estimator for indirect treatment effect comparisons in pharma drug development evidence synthesis, Bridged treatment comparison methodology for regulatory submissions without head-to-head trial data