G-computation for policy-relevant effects of interventions on time-to-event outcomes
Author: Alexander Breskin
View publication →Challenge
G-computation is a powerful tool for estimating policy-relevant causal effects of time-varying interventions on time-to-event outcomes, but practical implementation guidance including estimation, variance, and interpretation was not available in an accessible reference.
Solution
Target RWE researchers and UNC collaborators published a methodological paper providing accessible implementation guidance for g-computation applied to policy-relevant causal effects of interventions on time-to-event outcomes.
Impact
Providing accessible g-computation guidance for time-to-event outcomes advances practical adoption of this method in Target RWE's analytic toolkit, supporting capability to estimate causal effects of complex interventions for pharma partners with survival endpoint studies.
Use Cases / Links
G-computation implementation guidance for policy-relevant causal effects on time-to-event outcomes, Advanced causal methods toolkit development supporting pharma partner survival analysis studies