Using Instrumental Variables to Address Bias from Unobserved Confounders

Instrumental variable methods offer the potential to address unobserved confounding in observational studies, but their application, assumptions, and interpretation in comparative safety and effectiveness research were not accessible to a general clinical audience.

Target RWE's scientific advisor Alan Brookhart co-authored a JAMA Guide to Statistics and Methods on instrumental variable analysis, providing a non-technical accessible introduction to IV principles, assumptions, and interpretation.

Publication in JAMA of an accessible IV methods guide authored by Target RWE's scientific advisor establishes Brookhart and by association Target RWE as leading methodological authorities.

Instrumental variable methodology guide for addressing unobserved confounding in comparative effectiveness research, JAMA-published methodological authority positioning for Target RWE's scientific leadership